Silica-based nanoparticles for therapeutic protein delivery
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Updated: Aug 8, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Meihua Yu1, Zhengying Gu, Thomas Ottewell
1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. c.yu@uq.edu.au.
Abstract:
Nowadays, protein therapeutics receive unprecedented recognition for their great potential in the treatment of a variety of diseases. The efficacy of native therapeutic proteins is limited by their intrinsic poor stability and cell membrane permeability. Tremendous efforts have been devoted to developing efficient protein delivery systems. The past decade has witnessed the development and successful application of silica-based nanoparticles (SiNPs) as therapeutic protein carriers. This review focuses on recent advances in SiNPs in therapeutic protein delivery for disease and cancer treatment. The limitations of current studies and the room for improvement of SiNPs in therapeutic protein delivery are discussed.

