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Updated: Dec 24, 2025
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Low-power white light triggered AIE polymer nanoparticles with high ROS quantum yield for mitochondria-targeted and
Yadan Zheng1, Hongguang Lu, Zhu Jiang
1Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China. hglu@tjut.edu.cn hgao@tjut.edu.cn.
Abstract:
Photodynamic therapy (PDT) has received enormous attention due to its high specificity in eliminating the malignant tumor cells without interposing normal cells, as compared with chemotherapy. In this work, we fabricated mitochondria-targeted NPs using a new AIE cross-linked copolymer (PAIE-TPP) with far red/near-infrared (FR/NIR) subcellular bioimaging ability and a high reactive oxygen species (ROS) quantum yield of 77.9%. Such high efficiency ROS generation is desirable to increase the efficiency of PDT. The PAIE-TPP NPs possess great cytocompatibility but exert severe cytotoxicity to cancer cells with only 4% of cell viability under ultralow-power-intensity (10 mW cm-2) light irradiation. The AIE cross-linked copolymer NPs not only emit bright FR/NIR fluorescence for efficient in vitro subcellular-mitochondrial bioimaging but also generate high ROS for PDT.
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