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Preparation of Light-responsive Membranes by a Combined Surface Grafting and Postmodification Process

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Published on: March 21, 2014

A photo-tunable membrane based on inter-particle crosslinking for decreasing diffusion rates.

Song Li¹, Basem A Moosa, Ye Chen

¹Controlled Release and Delivery Laboratory (CRD), Center of Membrane and Porous Materials, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia. niveen.khashab@kaust.edu.sa.

Journal of Materials Chemistry. B

|April 9, 2020

Summary

Researchers developed photo-tunable composite membranes using photosensitive poly(hydroxycinnamic acid) microspheres. These membranes offer controllable permeability for applications like sustained drug release, demonstrating significant potential in material science.

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Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

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Published on: July 19, 2022

Area of Science:

Materials Science
Polymer Chemistry
Photochemistry

Background:

Functional polymeric membranes control molecular diffusion.
Photosensitive materials offer tunable properties.
Poly(hydroxycinnamic acid) (PHCA) exhibits photoreactivity.

Purpose of the Study:

To fabricate composite membranes with photo-tunable permeability.
To investigate the effect of UV light on membrane properties.
To demonstrate sustained drug release using the developed membrane.

Main Methods:

Fabrication of PHCA microspheres via emulsification solvent-evaporation.
Embedding PHCA microspheres into an ethyl cellulose matrix.
Characterization of membrane permeability and drug diffusion kinetics.

Main Results:

Inter-particle crosslinking in PHCA microspheres significantly reduced membrane permeability (74%).
UV irradiation decreased composite membrane permeability by 57%.
Sustained release of Rhodamine B from a model drug tablet over 10 days was achieved.

Conclusions:

PHCA-based composite membranes offer a promising platform for photo-tunable applications.
The developed membranes exhibit controllable permeability for drug delivery and separation.
The material demonstrates excellent processing reproducibility and consistent mechanical properties.