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Updated: Dec 24, 2025

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
Published on: November 20, 2018
Gd(iii) complex conjugated ultra-small iron oxide as an enhanced T1-weighted MR imaging contrast agent
Li Wang1, Hongwei Zhang, Zhiguo Zhou
1The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China. zgzhou@shnu.edu.cn johnmzhao@sjtu.edu.cn shipingy@shnu.edu.cn.
Abstract:
In this work, ultra-small iron oxide nanoparticles were synthesized using high temperature pyrolysis. For further functionalization, dopamine was anchored onto the surface of ultra-small iron oxide nanoparticles (Fe3O4@DOPA NPs). Gd(iii) ions were chelated with diethylenetriaminepentaacetic acid (DTPA) which was linked with dopamine. The resulting Gd(iii) complex conjugated ultra-small Fe3O4 NPs [Fe3O4@DOPA(Gd-DTPA) NPs] were characterized by XRD pattern and TEM. The longitudinal relaxivity (r1) of Fe3O4@DOPA(Gd-DTPA) NPs was 9.97 mM-1 S-1. Compared to ultra-small Fe3O4 NPs and Gd(iii) complexes, Fe3O4@DOPA(Gd-DTPA) NPs showed a significant improvement of the T1-weighted MR image in aqueous solution, in vitro and in vivo.
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