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Linkage of X-linked nephrogenic diabetes insipidus with DXS52, a polymorphic DNA marker
N Knoers1, H vd Heyden, B A von Oost
1Department of Human Genetics, Catholic University, Nijmegen, The Netherlands.
Nephron
|January 1, 1988
Abstract:
In five families with X-linked nephrogenic diabetes insipidus (NDI), linkage studies with the DNA marker DXS52, defined by probe St14, have shown no recombination with a maximum combined lod score of 6.40. These results assign the NDI gene to the subtelomeric region of the X chromosome long arm. This finding should facilitate identification of carriers and should also be helpful in finding the NDI gene itself.