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Updated: Dec 24, 2025

High Resolution Physical Characterization of Single Metallic Nanoparticles
Published on: June 28, 2019
Copper metal-organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for
1Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, Functional Molecules Analysis and Biotransformation Key laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, China. zhengliyan@ynu.edu.cn shxliu@ynu.edu.cn.
Abstract:
Enzyme-mimicking nanomaterials (nanozymes) have been used to catalyze enzyme-like reactions for various applications. Despite these favorable properties, peroxidase-mimicking nanozymes suffer from the optimum reaction occurring in acidic solutions, which greatly limits their applications in biological systems. Herein, we demonstrate that copper Metal-Organic Polyhedra (Cu-MOP) nanorods exhibit high peroxidase-mimicking activity at a physiological pH value. Cu-MOP nanorods catalyze the generation of strong chemiluminescence signals in the presence of luminol/H2O2 and the oxidation of 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate acid) (ABTS) by H2O2 produces a green color reaction in a neutral pH solution. The Cu-MOP nanorod driven generation of color reactions is applied to develop a H2O2 sensor, and furthermore is implemented to develop a glucose detection platform.
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