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Temperature and pH responsive 3D printed scaffolds.

Sujan Dutta1, Daniel Cohn

  • 1Casali Center of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. danielc@mail.huji.ac.il.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
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Researchers developed novel 3D printed hydrogels with dual responsiveness to temperature and pH. These smart materials offer fast, reversible dimensional changes, paving the way for advanced applications.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Developing smart materials with multiple environmental stimuli responses is crucial for advanced applications.
  • 3D printing techniques enable the fabrication of complex structures with tailored properties.

Purpose of the Study:

  • To develop novel 3D printed hydrogels exhibiting both reverse thermo-responsive (RTR) and pH-sensitive behaviors.
  • To investigate the synthesis and characterization of these dually responsive hydrogel constructs using stereolithography (SLA).

Main Methods:

  • Utilized methacrylated poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblocks as the base for RTR hydrogels.
  • Incorporated acrylic acid to impart pH sensitivity to the hydrogel formulations.

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  • Employed stereolithography (SLA) 3D printing to fabricate the dually responsive hydrogel structures.

    • Main Results:

    • The 3D printed hydrogels demonstrated significant water absorption and dimensional changes influenced by temperature and pH.
    • The hydrogels exhibited a rapid and reversible swelling-deswelling response across a pH range of 2.0 to 7.4.
    • Structures composed of two distinct dually responsive hydrogels were successfully printed, showcasing their environmentally sensitive dimensional behavior.

    Conclusions:

    • Novel dually responsive (RTR and pH-sensitive) hydrogels were successfully synthesized and 3D printed using SLA.
    • The developed materials show tunable dimensional changes in response to environmental stimuli, indicating potential for smart device applications.
    • The study highlights the feasibility of creating complex, multi-material constructs with integrated environmental responsiveness.