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Swim bladder collagen forms hydrogel with macroscopic superstructure by diffusion induced fast gelation.

Md Tariful Islam Mredha1, Xi Zhang, Takayuki Nonoyama

  • 1Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.

Journal of Materials Chemistry. B
|April 9, 2020
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Summary

Marine collagen from fish swim bladders forms stable, oriented hydrogels. This swim bladder collagen (SBC) offers superior thermal and mechanical properties compared to animal collagen, showing potential for tissue engineering.

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Area of Science:

  • Biomaterials Science
  • Biochemistry
  • Materials Engineering

Background:

  • Marine collagen presents a lower pathogen risk than animal collagen for medical applications.
  • Type I collagen from Bester sturgeon swim bladders exhibits unique properties like high denaturation temperature and solubility.

Purpose of the Study:

  • To explore the mechanism of superstructure formation in swim bladder collagen (SBC) hydrogels.
  • To compare the gelation and structural properties of SBC with traditional animal collagens.

Main Methods:

  • Controlled diffusion of neutral buffer through collagen solutions at room temperature.
  • Rheological analysis to determine mechanical properties.
  • Differential scanning calorimetry to assess thermal stability.

Main Results:

  • SBC formed stable, disk-shaped hydrogels with concentric collagen fiber orientation.
  • Animal collagens (calf and porcine skin) did not form stable, oriented structures using the same method.
  • SBC hydrogel denaturation temperature increased from 31°C to 43°C post-gelation, with a storage modulus >15 kPa.

Conclusions:

  • The fast fibrillogenesis rate of SBC drives the formation of oriented structures via diffusion-induced gelation.
  • SBC hydrogels possess enhanced thermal and mechanical stability, indicating suitability for tissue engineering.
  • This method offers a novel approach for creating advanced collagen-based biomaterials.