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Optical trapping for biosensing: materials and applications.

P Rodríguez-Sevilla1, L Labrador-Páez, D Jaque

  • 1Fluorescence Imaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, Madrid, Spain.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary

Optical trapping uses light forces to manipulate tiny particles for sensitive, non-invasive biological measurements. Recent advances in materials and techniques enable novel multifunctional probes for enhanced biosensing applications.

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Area of Science:

  • Biophysics
  • Nanotechnology
  • Optical Engineering

Background:

  • Optical trapping, pioneered in the 1970s, utilizes light forces to manipulate micro- and nanoparticles.
  • It has become a crucial tool for non-invasive, sensitive measurements, especially in biological applications.
  • Recent advancements in material synthesis have opened new avenues for multifunctional particles in biosensing.

Purpose of the Study:

  • To review recent experimental advances in biosensing using optical manipulation.
  • To provide a critical assessment of the current state-of-the-art in optical trapping for biosensing.
  • To discuss future prospects and challenges in the field.

Main Methods:

  • Summarizing recent experimental studies on optical manipulation of micro- and nanoparticles for biosensing.
  • Analyzing the synergy between new materials, experimental techniques, and biosensing applications.
  • Reviewing the design of novel optical systems and materials for advanced biosensing.

Main Results:

  • Demonstration of novel biosensing applications enabled by multifunctional particles.
  • Highlighting the power of optical trapping for sensitive, non-invasive measurements in biological systems.
  • Identification of key developments in materials and optical techniques driving biosensing progress.

Conclusions:

  • Optical trapping is a rapidly evolving field with significant potential in biosensing.
  • The development of new materials and sophisticated optical systems is crucial for future advancements.
  • Continued research promises enhanced capabilities for biosensing using optical manipulation.