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Grade I meningioma with disseminated bone disease: a rare clinical phenomenon
Oriol Mirallas1, David Marmolejo2, Augusto Valdivia2
1Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain urimirallas@gmail.com.
Abstract:
Meningioma, the second most common primary tumour of the central nervous system, is classified into three different grades based on their characteristics. Each tumour grade includes different molecular subtype, growth potential, and thus, different prognosis. Grade I meningioma is the most common subtype with a benign course, in which systemic dissemination rarely occurs. We present the case of a 48-year-old male patient with a history of grade I meningioma who was referred 3 years after the initial diagnosis to our centre due to pelvic pain. Computed tomography (CT) images showed new pelvic bone lesions whose histopathological report was compatible with a grade I meningioma. Neither hormonal therapy concomitant with octreotide nor hydroxiurea treatments were effective. Very little is known about this entity's prevalence and treatment when disseminated disease occurs. Thus, we think it is important to increase the positive and negative clinical experiences in this setting.
Insights
This case report details a rare instance of disseminated grade I meningioma presenting as pelvic bone lesions. It highlights the challenges in treating this rare presentation of a typically benign tumor.
Area of Science:
- Neuro-oncology
- Skeletal oncology
Background:
- Meningioma, the second most common primary central nervous system tumor, is graded I, II, or III.
- Grade I meningioma, typically benign, rarely disseminates systemically.
Observation:
- A 48-year-old male with a history of grade I meningioma presented with pelvic pain 3 years post-diagnosis.
- CT scans revealed new pelvic bone lesions, histopathologically confirmed as grade I meningioma.
Findings:
- The disseminated grade I meningioma showed resistance to hormonal therapy with octreotide and hydroxyurea.
- This case represents a rare occurrence of systemic dissemination of a low-grade meningioma.
Implications:
- Limited data exists on the prevalence and optimal treatment of disseminated meningioma.
- Sharing clinical experiences, both positive and negative, is crucial for advancing the management of rare meningioma presentations.
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