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Related Experiment Videos

LCBF values decline while L lambda values increase during normal human aging measured by stable xenon-enhanced

A Imai1, J S Meyer, M Kobari

  • 1Cerebral Blood Flow Laboratory, Veterans Administration Medical Center, Houston, Texas.

Neuroradiology
|January 1, 1988
PubMed
Summary
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Cerebral blood flow (CBF) and xenon transfer rate (λ) were measured in 32 adults. Advancing age correlated with decreased CBF in specific brain regions and increased λ in gray matter.

Area of Science:

  • Neuroimaging
  • Cerebrovascular Physiology
  • Gerontology

Background:

  • Cerebral blood flow (CBF) and xenon transfer rate (λ) are crucial physiological parameters.
  • Understanding age-related changes in these parameters is vital for assessing brain health.

Purpose of the Study:

  • To measure LCBF and L lambda values in neurologically normal individuals across a wide age range.
  • To investigate age-related changes in LCBF and L lambda.

Main Methods:

  • Utilized optimal CT-CBF methods with stable xenon inhalation (26-30%) for 8 minutes.
  • Serial scanning performed on a state-of-the-art CT scanner in 32 volunteers (aged 20-88 years).

Main Results:

  • LCBF was highest in frontal cortex gray matter and lowest in occipital cortex gray matter.

Related Experiment Videos

  • Significant age-related declines in LCBF were observed in occipital cortex and frontal white matter.
  • Significant age-related increases in L lambda were measured in frontal/temporal cortex and subcortical structures like the thalamus.

    • Conclusions:

    • Age impacts cerebral blood flow and xenon transfer rates, with regional variations.
    • Increased L lambda with age may be linked to neuronal lipofuscin accumulation or gray matter compaction.