The catalytic activity of monomeric yeast hexokinase A

It has been suggested [Williams, D.C. & Jones, J.G. (1976) Biochem. J. 155, 661-667] that monomeric hexokinase isoenzyme A is not catalytically active. We here present data from reacting-enzyme sedimentation, dissociation experiments and from previous studies which are consistent with the monomeric form possessing catalytic activity.