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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Intracellular Signaling Affects Focal Adhesions01:17

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
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A Pro-resolving Role for Galectin-1 in Acute Inflammation.

Hannah L Law1, Rachael D Wright1,2, Asif J Iqbal3

  • 1The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Frontiers in Pharmacology
|April 9, 2020
PubMed
Summary

Galectin-1 (Gal-1) promotes the resolution of acute inflammation by reducing neutrophil recruitment and enhancing their clearance. This immune-regulatory protein accelerates the healing process, as demonstrated in a murine model.

Keywords:
apoptosisgalectin-1inflammationleukocytesresolution

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Area of Science:

  • Immunology
  • Inflammation Resolution
  • Molecular Biology

Background:

  • Galectin-1 (Gal-1) exhibits immune-regulatory and anti-inflammatory effects.
  • Gal-1 release correlates with inflammation peaks, suggesting a pro-resolving role.
  • Its precise function in inflammation resolution requires further elucidation.

Purpose of the Study:

  • To investigate the role of Galectin-1 in resolving acute inflammation.
  • To determine if Gal-1 inhibits neutrophil recruitment and enhances neutrophil clearance.
  • To explore the therapeutic potential of Gal-1 in inflammation resolution.

Main Methods:

  • Utilized a murine model of self-resolving inflammation.
  • Employed Galectin-1 null mice and administered recombinant Gal-1.
  • Quantified neutrophil recruitment and apoptosis in peritoneal lavage fluid.

Main Results:

  • Galectin-1 null mice exhibited enhanced neutrophil recruitment during early zymosan peritonitis.
  • Administration of recombinant Gal-1 reduced neutrophil numbers and shortened the resolution interval.
  • Gal-1 treatment promoted neutrophil apoptosis, indicating a pro-resolving action.

Conclusions:

  • Galectin-1 plays a crucial role in the timely resolution of acute inflammation.
  • Gal-1's pro-resolving properties are mediated through inhibition of neutrophil recruitment and potentiation of neutrophil clearance.
  • Targeting Gal-1 may offer therapeutic strategies for inflammatory conditions.