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Updated: Dec 24, 2025

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
Published on: January 12, 2020
Nuclear Factor κB (NF-κB)-Mediated Inflammation in Multiple Sclerosis
Yifan Zhou1, Chunping Cui1, Xiaoyu Ma1
1Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Abstract:
The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets.
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