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The Emerging Roles of NDR1/2 in Infection and Inflammation

Xiaolan Ye1, Naomi Ong1, Huazhang An2

  • 1Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Immunology
|April 9, 2020
PubMed

Insights

Nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 regulate inflammation and immune responses. This review details their roles in cytokine signaling, bacterial, and viral infections via Hippo pathway-dependent and -independent mechanisms.

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • Nuclear Dbf2-related (NDR) kinases, NDR1 and NDR2, are conserved components of the Hippo signaling pathway.
  • NDR1/2 are known regulators of fundamental cellular processes including cell proliferation and apoptosis.
  • Emerging evidence highlights NDR1/2 involvement in immune system regulation.

Purpose of the Study:

  • To review the functions of NDR1/2 in modulating inflammation.
  • To summarize the roles of NDR1/2 in innate immune responses to bacterial and viral infections.
  • To elucidate the signaling mechanisms, both dependent and independent of the Hippo pathway, by which NDR1/2 exert their functions.

Main Methods:

  • Literature review of recent studies on NDR1/2.
  • Analysis of signaling pathways regulated by NDR1/2.
  • Integration of findings on NDR1/2 in inflammation and immunity.

Main Results:

  • NDR1/2 modulate inflammation induced by cytokines.
  • NDR1/2 are critical for innate immune responses against bacterial and viral pathogens.
  • NDR1/2 regulate cellular signaling through both Hippo pathway-dependent and -independent routes.

Conclusions:

  • NDR1/2 play significant roles in the immune system, impacting inflammation and host defense.
  • Understanding NDR1/2 signaling mechanisms provides insights into potential therapeutic targets for inflammatory and infectious diseases.
Keywords:
Hippo signaling pathwayNDR1NDR2infectioninflammationinnate immunity

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