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A comprehensive review of the roles of E2F1 in colon cancer

Zejun Fang1,2, Min Lin1, Chunxiao Li3

  • 1Central Laboratory, Sanmen People's Hospital of Zhejiang, Sanmenwan Branch of The First Affiliated Hospital, College of Medicine, Zhejiang University Sanmen 317100, China.

American Journal of Cancer Research
|April 9, 2020
PubMed

Insights

E2F transcription factor 1 (E2F1) plays a dual role in colon cancer, promoting tumor growth and apoptosis. This review consolidates scattered research on E2F1

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • E2F transcription factor 1 (E2F1) is crucial for cell cycle regulation.
  • E2F1 influences proliferation, differentiation, apoptosis, metastasis, and chemoresistance in colon cancer.
  • Existing research on E2F1 in colon cancer is fragmented across various genes and microRNAs.

Purpose of the Study:

  • To provide the first comprehensive review of E2F1's complex roles in colon cancer.
  • To analyze and synthesize current understanding of E2F1 in colon cancer.
  • To guide future research directions.

Main Methods:

  • Literature review and synthesis of experimental data.
  • Analysis of E2F1's pro-tumorigenic and pro-apoptotic functions.
  • Examination of genes and microRNAs affecting E2F1 expression in colon cancer.

Main Results:

  • E2F1 exhibits both pro-tumorigenic and pro-apoptotic activities in colon cancer.
  • E2F1 is implicated in colon cancer cell proliferation, differentiation, apoptosis, metastasis, and chemoresistance.
  • Research findings on E2F1's impact are dispersed across numerous studies.

Conclusions:

  • A consolidated understanding of E2F1's multifaceted roles in colon cancer is needed.
  • Further research is essential to elucidate E2F1's precise mechanisms and therapeutic potential in colon cancer.
  • This review serves as a foundational resource for future investigations into E2F1 in colon cancer.
Keywords:
E2F1apoptosischemoresistancecolon cancerproliferation

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