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Related Concept Videos

Regulation of Heart Rates01:31

Regulation of Heart Rates

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The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Dec 24, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Exercise Mediates Heart Protection via Non-coding RNAs.

Yuelin Zhang1,2, Nana He2,3, Beili Feng1,2

  • 1Department of Cardiology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

Frontiers in Cell and Developmental Biology
|April 9, 2020
PubMed
Summary
This summary is machine-generated.

Regular exercise training protects the heart from cardiovascular events (CVDs). Non-coding RNAs (ncRNAs) are promising biomarkers and therapeutic targets for preventing and treating CVDs.

Keywords:
cardiovascular diseasesexercisemicroRNAnon-coding RNAoxidative stress

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Exercise Physiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Regular exercise is a recognized strategy for cardiovascular event prevention.
  • Non-coding RNAs (ncRNAs) show potential as biomarkers and therapeutic targets for CVDs.

Purpose of the Study:

  • To review the role of ncRNAs in exercise-induced cardiac protection.
  • To explore ncRNAs as potential therapeutic targets for CVDs.
  • To assess ncRNAs for CVD prevention strategies.

Main Methods:

  • Literature review of studies on ncRNAs and exercise.
  • Analysis of regulatory mechanisms of ncRNAs in cardiac protection.
  • Synthesis of evidence on ncRNAs for CVD therapy and prevention.

Main Results:

  • ncRNAs play a significant role in mediating the cardiac benefits of exercise.
  • Specific ncRNAs are identified as key regulators in exercise-induced cardioprotection.
  • ncRNAs offer novel avenues for therapeutic interventions in CVDs.

Conclusions:

  • ncRNAs are crucial in exercise-mediated cardiac protection.
  • Targeting ncRNAs presents a promising strategy for CVD prevention and treatment.
  • Further research into ncRNAs can advance cardiovascular medicine.