Related Experiment Video
Updated: Dec 24, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
Immunotherapy: From Advanced NSCLC to Early Stages, an Evolving Concept
Thierry Berghmans1, Valérie Durieux2, Lizza E L Hendriks3
1Clinic of Thoracic Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Immunotherapy, particularly checkpoint inhibitors like anti-PD1/PD-L1, has significantly improved survival for advanced non-small cell lung cancer (NSCLC). Combinations show promise, but optimal patient selection and treatment strategies require further research.
Area of Science:
- Oncology
- Immunology
- Clinical Trials
Background:
- Immunotherapy has a complex history in lung cancer treatment, with recent breakthroughs in advanced and metastatic non-small cell lung cancer (NSCLC).
- Checkpoint inhibitors targeting PD-1/PD-L1 have demonstrated significant survival benefits compared to traditional chemotherapy.
- Anti-CTLA4 therapies have shown limited success in unselected patients, but combinations with anti-PD1 are promising.
Conclusions:
- Checkpoint inhibitors represent a major advance in advanced NSCLC treatment, offering improved survival and quality of life.
- Combination therapies, particularly anti-PD1 with anti-CTLA4, show potential.
- Further research is needed to optimize treatment duration, patient selection, and identify novel therapeutic targets and combinations.
More Related Videos
09:04Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
07:55Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
Related Concept Videos
Tumor Immunotherapy
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers