Differential responsiveness to lithium in patients with Tourette disorder

The current status of the use of lithium in the treatment of tic disorders is reviewed. Areas of pathophysiologic overlap between bipolar and tic symptomatology are explored from the standpoint of shared etiology versus co-morbidity. Data from ten cases of children and adolescents with tic disorders treated with lithium are presented. Five exhibited a positive response to tic and associated symptoms, while five did not. Treatment responders versus nonresponders were compared along a number of parameters including co-morbidity with other syndromes, family history, prior medication history, medication used concurrently with lithium, and medication used subsequent to treatment with lithium. Differences between the two groups are explored.