Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

187
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
187
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

2.7K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.7K
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

509
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
509
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

1.0K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond the scalpel: rare and experimental nonsurgical treatments for basal cell carcinoma.

Dermatology online journal·2026
Same author

Primary Cutaneous Cryptococcosis in Immunocompetent Patients: Recognition and Management.

American journal of clinical dermatology·2026
Same author

Occupational Risk of Sexually Transmitted Infections in Aesthetic Dermatology and Dermatologic Surgery: Evidence and Prevention.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Ramadan and isotretinoin initiation: When deferral is the ethical choice.

Journal of the American Academy of Dermatology·2026
Same author

Clinical Updates on Birt-Hogg-Dubé Syndrome and Atypical Presentations: Diagnosis and Management.

Dermatology practical & conceptual·2026
Same author

The ethics of commercializing surgical discards.

Journal of the American Academy of Dermatology·2026

Related Experiment Video

Updated: Dec 24, 2025

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion
06:24

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion

Published on: April 21, 2023

1.8K

Pain-less injection: principles and pearls.

Yi Chun Lai1, Amor Khachemoune2

  • 1Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Archives of Dermatological Research
|April 9, 2020
PubMed
Summary

Minimizing pain during dermatologic procedures is crucial. This study introduces a novel technique for local anesthetic injections, focusing on distraction and avoiding visual cues to enhance patient comfort and reduce procedural pain.

Keywords:
InjectionLocal anesthesiaPainSensory feedback

More Related Videos

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.8K
Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

9.9K

Related Experiment Videos

Last Updated: Dec 24, 2025

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion
06:24

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion

Published on: April 21, 2023

1.8K
Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.8K
Development of Recombinant Proteins to Treat Chronic Pain
10:37

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

9.9K

Area of Science:

  • Dermatology
  • Pain Management
  • Anesthesiology

Background:

  • Dermatologic procedures have increased significantly, leading to greater use of local anesthetics.
  • Local anesthetic administration is often the most painful aspect of cutaneous procedures.
  • Pain perception is influenced by sensory feedback and anxiety.

Purpose of the Study:

  • To present a novel method for minimizing pain and discomfort during local anesthetic injections.
  • To improve patient experience during dermatologic procedures.

Main Methods:

  • The authors describe a technique involving keeping syringes and needles out of sight.
  • Injection is performed without prior warning to the patient.
  • Patients are engaged in conversation or simple tasks during the procedure.

Main Results:

  • The proposed method aims to achieve painless local anesthetic injections.
  • This technique focuses on managing patient perception of pain and anxiety.

Conclusions:

  • Painless local anesthetic injection is achievable through specific patient management strategies.
  • Implementing these techniques can significantly improve patient comfort during dermatologic procedures.