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Historical overview of the interleukin-6 family cytokine

Sujin Kang1, Masashi Narazaki2,3, Hozaifa Metwally1

  • 1Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, Osaka, Japan.

The Journal of Experimental Medicine
|April 9, 2020
PubMed

Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple pathways, using both membrane and soluble IL-6 receptors. As indicated by the expanding market for IL-6 inhibitors, it has become a primary therapeutic target among IL-6 family cytokines. Here, we revisit the discovery of IL-6; discuss insights regarding the roles of this family of cytokines; and highlight recent advances in our understanding of regulation of IL-6 expression.

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