Hepatic Cystic Echinococcosis (Hydatid Cyst) in a Six Year Old

A Ali1, K M Butler1, C Brenner2

  • 1Department of Paediatric Infectious Diseases, Children's Health Ireland at Crumlin, Dublin 12.

Irish Medical Journal
|April 9, 2020
PubMed

Insights

Cystic echinococcosis (CE) in children, often asymptomatic, requires considering travel history for diagnosis. Early detection and treatment, including surgery and albendazole, are crucial for managing this parasitic infection.

Area of Science:

  • Medical Parasitology
  • Pediatric Infectious Diseases
  • Hepatology

Background:

  • Cystic echinococcosis (CE), caused by Echinococcus granulosus, is a zoonotic parasitic disease.
  • While prevalent in some regions, CE cases in children, particularly in Ireland, warrant epidemiological review.
  • Asymptomatic liver cysts in children necessitate a thorough differential diagnosis.

Observation:

  • A previously healthy 6-year-old girl presented with an asymptomatic liver cyst.
  • Diagnostic workup included positive serology for Echinococcus granulosus and suggestive radiological findings.
  • Histopathology confirmed CE due to E. granulosus.

Findings:

  • The child's infection was likely acquired during travel to continental Europe.
  • Surgical resection (liver segmentectomy) combined with pre- and post-operative albendazole treatment was effective.
  • This case highlights the importance of considering CE in pediatric liver cystic lesions.

Implications:

  • CE should be included in the differential diagnosis for children presenting with asymptomatic liver or lung cysts.
  • Eliciting a detailed travel history is critical for diagnosing CE in pediatric cases.
  • This case underscores the need for increased awareness of CE in non-endemic areas or among travelers.

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
134
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
150
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
194
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
176