Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Implications of Alpha-gal Syndrome in Urologic Management.

Urology·2026

Same author

Hippocampal volume alterations in opioid use disorder: Evidence for posterior vulnerability and heterogeneity.

Drug and alcohol dependence·2026

Same author

Retinol-guided liposomal platform for targeted pirfenidone delivery in hepatic fibrosis.

Journal of nanobiotechnology·2026

Same author

Combinatorial optimization enhanced by shallow quantum circuits with 104 superconducting qubits.

National science review·2026

Same author

Loss of salivary agglutinin induces changes in the salivary microbiome and accelerates development of oral cancer.

Microbiome·2026

Same author

Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose.

Addiction neuroscience·2026

Search research articles

Related Experiment Video

Updated: Dec 24, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis.

Amy I Yu¹, Lili Zhao², Kathryn A Eaton³

¹Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

|April 9, 2020

Summary

This summary is machine-generated.

Gut microbiome imbalance (dysbiosis) impacts colorectal cancer. This study shows dysbiosis promotes colon tumors by overstimulating CD8 T cells, leading to inflammation and reduced anti-tumor immunity.

Keywords:

CD8 T cells T cell exhaustion colitis colon cancer inflammation microbiome

More Related Videos

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Related Experiment Videos

Last Updated: Dec 24, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

Area of Science:

Immunology
Microbiology
Oncology

Background:

Gut microbiome dysbiosis is increasingly linked to colorectal cancer development.
Understanding the mechanisms of microbiome influence on cancer susceptibility is crucial.

Purpose of the Study:

To investigate how distinct gut microbial communities affect tumor development in a mouse model.
To elucidate the role of adaptive immune cells in microbiome-mediated cancer susceptibility.

Main Methods:

Utilized a mouse model of inflammation-associated tumorigenesis with two wild-type mouse colonies exhibiting different gut microbial communities.
Analyzed adaptive immune cell populations, specifically CD8+ IFNγ+ T cells, in the colon lamina propria and tumor tissues.

Main Results:

Mice with more tumors showed increased CD8+ IFNγ+ T cells in the colon lamina propria prior to tumorigenesis.
These mice also exhibited reduced CD8+ IFNγ+ T cells within tumors and adjacent tissues, alongside increased T cell exhaustion.
Conversely, mice with fewer tumors displayed different immune cell profiles.

Conclusions:

Microbial dysbiosis can enhance colon tumor susceptibility by promoting chronic inflammation through hyperstimulation of CD8 T cells.
Early T cell exhaustion, driven by dysbiosis, may impair the host's anti-tumor immune response.