Related Experiment Video

Updated: Dec 24, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Relationship between Microfibrillar-Associated Protein 4 Levels and Subclinical Myocardial Damage in Chronic Kidney

Sonat Pınar Kara1, Gülsüm Özkan2, Demet Özkaramanlı Gür3

  • 1Department of Internal Medicine, Tekirdağ Namık Kemal University School of Medicine, Tekirdağ, Turkey.

Cardiorenal Medicine
|April 9, 2020
PubMed
Abstract

Insights

Microfibrillar-associated protein 4 (MFAP4) levels are elevated in chronic kidney disease (CKD) patients, correlating with impaired heart function. This suggests MFAP4 may serve as a novel biomarker for cardiovascular evaluation in CKD.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is a major health concern, with cardiovascular diseases being the leading cause of mortality.
  • Microfibrillar-associated protein 4 (MFAP4), an extracellular matrix protein, is crucial for vascular integrity and remodeling.
  • Existing literature lacks data on MFAP4 levels in CKD and its association with myocardial function.

Purpose of the Study:

  • To investigate MFAP4 levels in CKD patients.
  • To identify factors influencing MFAP4 levels in CKD.
  • To explore the relationship between MFAP4 and myocardial function in CKD.

Main Methods:

  • Study included 79 CKD patients and 30 healthy controls.
  • Demographic data, routine biochemical tests, and echocardiography were performed.
  • Blood samples were analyzed for MFAP4 levels, with statistical analysis of results.

Main Results:

  • MFAP4 levels were significantly higher in CKD patients compared to controls (p<0.001).
  • CKD patients exhibited more frequent left ventricular (LV) diastolic impairment.
  • Subclinical LV systolic dysfunction was evident in CKD patients, with impaired tissue Doppler systolic velocity and global longitudinal strain.
  • Elevated MFAP4 positively correlated with aortic root (AR) dimensions and global circumferential strain (GCS) and its rate.

Conclusions:

  • This study reports elevated MFAP4 levels in CKD for the first time.
  • MFAP4 elevation may be linked to GCS and AR dilation in CKD patients.
  • MFAP4 could potentially serve as a biomarker for assessing myocardial function in CKD, pending further research.
Keywords:
Chronic kidney diseaseChronic renal failureMFAP4Microfibrillar-associated protein 4Myocardial functions

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.7K
A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model07:01

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

1.8K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
478
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
473
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
236
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
270
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
118
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
212