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Role of Deubiquitinases in Human Cancers: Potential Targeted Therapy

Keng Po Lai1, Jian Chen1, William Ka Fai Tse2

  • 1Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, China.

International Journal of Molecular Sciences
|April 10, 2020
PubMed

Insights

Deubiquitinases (DUBs) regulate protein stability and cellular functions. This review explores DUBs

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Deubiquitinases (DUBs) are critical enzymes that remove ubiquitin (UBQ) tags from proteins, thereby regulating protein stability, activity, and localization.
  • Dysregulation of deubiquitylation processes by DUBs has been implicated in the pathogenesis of various human cancers.
  • Understanding the specific roles of DUBs in cancer development and progression is crucial for identifying novel therapeutic strategies.

Purpose of the Study:

  • To review and evaluate the multifaceted biological roles of DUBs in cancer.
  • To elucidate the mechanisms by which DUBs regulate key cancer-associated processes such as proliferation, cell cycle control, apoptosis, and DNA damage response.
  • To discuss the potential of DUBs as therapeutic targets for effective cancer treatment.

Main Methods:

  • Comprehensive literature review of studies investigating deubiquitinase functions in cancer.
  • Analysis of biochemical regulation and posttranslational modifications governing DUB activity.
  • Evaluation of the impact of DUBs on downstream effectors and signaling pathways in cancer.

Main Results:

  • DUBs play significant roles in cancer, influencing tumor suppression, oncogenesis, and metastasis.
  • Specific DUBs regulate critical cellular pathways involved in cancer development.
  • The review summarizes the intricate relationship between DUBs and human cancers.

Conclusions:

  • Deubiquitinases are pivotal regulators in cancer biology, impacting multiple hallmarks of cancer.
  • Targeting DUBs presents a promising therapeutic avenue for cancer treatment.
  • Further research into DUBs' functions is essential for advancing cancer therapy.
Keywords:
cancerdegradationdeubiquitinasetherapeutic target

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