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Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
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BSA loaded bead-on-string nanofiber scaffold with core-shell structure applied in tissue engineering.

Tingxiao Li1, Lei Wang1, Yifan Huang1

  • 1School of Textile and Fashion, Shanghai University of Engineering Science, Shanghai, China.

Journal of Biomaterials Science. Polymer Edition
|April 10, 2020
PubMed
Summary

Poly (L-lactic acid-co-ε-caprolactone) (PLCL) beaded nanofibers with a core-shell structure show sustained drug release for tissue engineering. These biocompatible nanofibers effectively support human mesenchymal stem cell attachment and proliferation.

Keywords:
Poly (L-lactic acid-co-ε-caprolactone)beaded nanofiberbovine serum albumincore-shell structurehuman mesenchymal stem cellstissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Delivery Systems

Background:

  • Beaded nanofibers offer sustained drug release for regulating cell behaviors in tissue engineering.
  • Core-shell structures enhance the functionality of nanofibers for biomedical applications.

Purpose of the Study:

  • To fabricate and characterize Poly (L-lactic acid-co-ε-caprolactone) (PLCL) beaded nanofibers with a core-shell structure encapsulating bovine serum albumin (BSA).
  • To evaluate the degradation properties and in vitro biocompatibility of the fabricated PLCL/BSA core-shell nanofibers using human mesenchymal stem cells (hMSCs).

Main Methods:

  • Fabrication of PLCL/BSA core-shell beaded nanofibers.
  • Surface morphology and characteristic analysis using scanning electron microscopy (SEM) and water contact angle tests.
  • In vitro degradation studies and cell culture with hMSCs, assessed via alamar blue reagent and SEM for cell morphology.

Main Results:

  • PLCL/BSA core-shell beaded nanofibers maintained structural integrity for 3 weeks.
  • SEM and microscopy confirmed the core-shell structure and surface characteristics.
  • In vitro studies demonstrated excellent biocompatibility, supporting hMSC attachment, proliferation, and spreading.

Conclusions:

  • PLCL beaded nanofibers with a core-shell structure are a promising platform for sustained drug delivery.
  • These core-shell nanofibers effectively support cell attachment and proliferation, indicating potential for tissue engineering applications.