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Published on: February 24, 2023
Therapeutics and Research Related to Glioblastoma: Advancements and Future Targets
Vishal Chavda1, Vimal Patel2, Dhananjay Yadav3
1Department of Pharmacology, Nirma University, Ahmadabad, Gujarat, 382481, India.
Abstract:
Glioblastoma, the most common primary brain tumor, has been recognized as one of the most lethal and fatal human tumors. It has a dismal prognosis, and survival after diagnosis is less than 15 months. Surgery and radiotherapy are the only available treatment options at present. However, numerous approaches have been made to upgrade in vivo and in vitro models with the primary goal of assessing abnormal molecular pathways that would be suitable targets for novel therapeutic approaches. Novel drugs, delivery systems, and immunotherapy strategies to establish new multimodal therapies that target the molecular pathways involved in tumor initiation and progression in glioblastoma are being studied. The goal of this review was to describe the pathophysiology, neurodegeneration mechanisms, signaling pathways, and future therapeutic targets associated with glioblastomas. The key features have been detailed to provide an up-to-date summary of the advancement required in current diagnosis and therapeutics for glioblastoma. The role of nanoparticulate system graphene quantum dots as suitable therapy for glioblastoma has also been discussed.
Insights
Glioblastoma is a deadly brain cancer with poor survival rates. This review explores its pathophysiology and potential new therapies, including graphene quantum dots, to improve glioblastoma treatment.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Nanomedicine
Background:
- Glioblastoma is the most common and lethal primary brain tumor, with survival under 15 months.
- Current treatments (surgery, radiotherapy) are limited, necessitating novel therapeutic strategies.
- Understanding molecular pathways is crucial for developing effective glioblastoma treatments.
Purpose of the Study:
- To review glioblastoma pathophysiology, neurodegeneration, and signaling pathways.
- To summarize current advancements in glioblastoma diagnosis and therapeutics.
- To discuss novel therapeutic targets and delivery systems for glioblastoma.
Main Methods:
- Literature review of glioblastoma pathophysiology and molecular mechanisms.
- Analysis of current and emerging diagnostic and therapeutic approaches.
- Exploration of nanoparticulate systems, specifically graphene quantum dots, for glioblastoma therapy.
Main Results:
- Glioblastoma presents significant challenges due to its aggressive nature and limited treatment options.
- Numerous molecular pathways are implicated in glioblastoma initiation and progression.
- Graphene quantum dots show potential as a therapeutic agent for glioblastoma.
Conclusions:
- Further research into molecular pathways is essential for advancing glioblastoma treatment.
- Novel multimodal therapies targeting glioblastoma's molecular underpinnings are under investigation.
- Nanoparticulate systems like graphene quantum dots offer promising avenues for future glioblastoma therapy.
