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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement

Rupesh Raina1,2, Jirair K Bedoyan3, Uta Lichter-Konecki4

  • 1Department of Nephrology, Akron Children's Hospital, Akron, OH, USA. rraina@akronchildrens.org.

Nature Reviews. Nephrology
|April 10, 2020
PubMed

Insights

Hyperammonaemia in children can cause severe harm. This expert consensus provides recommendations for managing hyperammonaemia in pediatric patients using extracorporeal therapies like kidney replacement therapy (KRT).

Area of Science:

  • Pediatric Nephrology
  • Critical Care Medicine
  • Metabolic Disorders

Background:

  • Hyperammonaemia in children poses significant risks, including cerebral edema, neurological impairment, and mortality.
  • Common causes in infants and children include urea cycle disorders and organic acidaemias.
  • Limited research exists on extracorporeal therapies for neonatal and pediatric hyperammonaemia.

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