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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Amyloid Fibrils03:03

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Related Experiment Video

Updated: Dec 24, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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Systemic amyloidosis: moving into the spotlight.

Oliver C Cohen1, Ashutosh D Wechalekar2,3

  • 1National Amyloidosis Centre, University College London (Royal Free Campus), London, UK.

Leukemia
|April 10, 2020
PubMed
Summary
This summary is machine-generated.

Diagnosing systemic amyloidosis early is crucial for better outcomes. Recent advances in diagnostics, risk stratification, and novel treatments are improving patient survival and organ function.

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Area of Science:

  • Hematology
  • Internal Medicine
  • Pathology

Background:

  • Systemic amyloidosis is a rare, heterogeneous disease with challenging early diagnosis.
  • Timely diagnosis is vital for improving prognosis and preventing organ damage.

Purpose of the Study:

  • To review recent advancements in the diagnosis and treatment of systemic amyloidosis.
  • To highlight improvements in diagnostic techniques, risk stratification, and therapeutic strategies.

Main Methods:

  • Review of current literature and available data on systemic amyloidosis.
  • Analysis of emerging diagnostic imaging and histological techniques.
  • Evaluation of novel therapeutic agents and emerging treatment strategies.

Main Results:

  • Diagnostic capabilities have improved with new imaging and histological methods.
  • Biomarkers and cytogenetics enhance risk stratification and treatment decisions.
  • Novel agents have demonstrated improved treatment efficacy and survival benefits.

Conclusions:

  • Recent advances significantly improve the diagnosis and management of systemic amyloidosis.
  • Ongoing research into novel therapies promises further improvements in patient outcomes.