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Modulation of regulatory T cell function and stability by co-inhibitory receptors
Liliana E Lucca1, Margarita Dominguez-Villar2
1Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Nature Reviews. Immunology
|April 10, 2020
Summary
Regulatory T (Treg) cells are crucial for immune control. Targeting their co-inhibitory receptors offers potential therapies for autoimmunity and cancer by modulating Treg cell function.
Area of Science:
- Immunology
- Cell Biology
- Therapeutics
Background:
- Regulatory T (Treg) cells are vital for immune homeostasis, with altered function and numbers implicated in autoimmunity and cancer.
- Therapeutic strategies are exploring Treg cell modulation to manage immune responses in these diseases.
Purpose of the Study:
- To review the role of co-inhibitory receptors in controlling Treg cell function and stability.
- To highlight the therapeutic potential of targeting these receptors in autoimmunity and cancer.
Main Methods:
- Literature review of recent research on co-inhibitory molecules and Treg cells.
- Analysis of Treg cell function, stability, and plasticity in disease contexts.
Main Results:
- Co-inhibitory receptors preferentially expressed by Treg cells influence their function and stability.
- These receptors are key targets for modulating Treg cell activity.
Conclusions:
- Targeting co-inhibitory receptors on Treg cells presents a promising therapeutic avenue for treating autoimmune diseases and cancer.
- Modulating Treg cell plasticity via these receptors can restore immune balance.
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