Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antioxidative Carbon Dot-Reinforced Polymer Electrolytes Enabling 4.8 V High-Voltage Solid-State Lithium Metal Batteries.

ACS applied materials & interfaces·2026
Same author

Lignin-based flame retardant containing nitrogen and phosphorus coordinated by Fe<sup>3+</sup> for TPU.

International journal of biological macromolecules·2026
Same author

Quaternized-PAF Architecture Mediated Proton Channels to Enhance Ultra-Robust Operation for 200 °C Proton Exchange Membrane Fuel Cells.

Angewandte Chemie (International ed. in English)·2025
Same author

Dual Ratiometric Fluorescence Sensors Based on Chiral Carbon Dots for the Sensitive and Specific Detection of Arginine.

Analytical chemistry·2025
Same author

The Cardioprotective Effect of Ginseng Derived Exosomes via Inhibition of Oxidative Stress and Apoptosis.

ACS applied bio materials·2024
Same author

A Multi-Functional Cascade Nanoreactor for Remodeling Tumor Microenvironment to Realize Mitochondria Dysfunction via ROS/Zn<sup>2+</sup> Ions Overload.

Small (Weinheim an der Bergstrasse, Germany)·2024

Related Experiment Video

Updated: Dec 24, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.0K

Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics.

Qian Chen1, Xueru Shan1, Suqing Shi1

  • 1Jilin Province Key Laboratory of Carbon Fiber Development and Application, School of Chemistry and Life Science, Changchun University of Technology, 2055 Yanan Street, Changchun 130012, P. R. China. sunguoying@ccut.edu.cn.

Journal of Materials Chemistry. B
|April 10, 2020
PubMed
Summary
This summary is machine-generated.

A novel polydopamine-based theranostic agent (PDA@TA-Fe) enables dual-mode cancer therapy. This agent combines photothermal therapy and acidity-activated chemodynamic therapy for enhanced tumor suppression and real-time imaging.

More Related Videos

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.4K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.0K

Related Experiment Videos

Last Updated: Dec 24, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.0K
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.4K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Therapy

Background:

  • Theranostic agents integrate diagnosis and therapy for improved cancer treatment.
  • Real-time imaging guidance enhances the precision of tumor treatment.
  • Polydopamine (PDA)-based materials offer versatile platforms for theranostic applications.

Purpose of the Study:

  • To develop a novel core-shell polydopamine-based theranostic agent (PDA@TA-Fe).
  • To investigate the synergistic therapeutic effects of photothermal therapy (PTT) and chemodynamic therapy (CDT).
  • To evaluate the agent's efficacy in T1/T2 MR imaging-guided cancer treatment.

Main Methods:

  • Fabrication of a core-shell PDA@TA-Fe theranostic agent using a two-step strategy.
  • Assessment of photothermal conversion efficiencies under 808 nm and 1064 nm laser irradiation.
  • Evaluation of acidity-triggered Fe3+ to Fe2+ reduction and subsequent hydroxyl radical generation via Fenton reaction in the tumor microenvironment (TME).
  • In vivo studies including tumor-xenograft imaging (T1/T2-weighted MR) and therapeutic assays.

Main Results:

  • PDA@TA-Fe exhibited high photothermal conversion efficiencies (29% at 808 nm, 41% at 1064 nm).
  • The agent demonstrated acidity-activated chemodynamic therapy, generating hydroxyl radicals (˙OH) in the TME.
  • Synergistic PTT and CDT effects were observed, with heat accelerating ˙OH generation.
  • In vivo studies showed enhanced permeation and retention (EPR) effect, significant tumor suppression, and clear MR imaging contrast.

Conclusions:

  • The developed PDA@TA-Fe agent serves as an effective platform for T1/T2 MR imaging-guided synergistic cancer therapy.
  • The combination of PTT and CDT offers a promising strategy for enhanced tumor treatment.
  • This study presents a novel "all-in-one" nanoplatform for advanced cancer theranostics.