Anaphylaxis caused by butylscopolamine bromide: a case report
Toshie Shiraishi1, Mitsuyo Nakamura1, Tatsuo Horiuchi2
1Department of Anesthesia, Minimally Invasive Surgery Center, Yotsuya Medical Cube, 7-7 Niban-cho, Chiyoda-ku, Tokyo, 102-0084, Japan.
JA Clinical Reports
|April 10, 2020
Summary
Butylscopolamine, an anticholinergic drug, can cause severe anaphylaxis. This case highlights the importance of identifying butylscopolamine as the cause to prevent future allergic reactions.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Gastroenterology
Background:
- Butylscopolamine is a widely used anticholinergic agent with limited reported cases of anaphylaxis.
- This study presents a rare instance of severe anaphylaxis attributed to butylscopolamine administration.
Purpose of the Study:
- To report a case of anaphylaxis induced by butylscopolamine.
- To emphasize the significance of identifying butylscopolamine as the causative agent in anaphylactic reactions.
Main Methods:
- A 63-year-old woman experienced anaphylaxis following intravenous butylscopolamine.
- Diagnosis was supported by elevated plasma histamine and serum tryptase levels.
- Specific diagnosis was confirmed via skin and basophil activation tests (CD203c, CD63).
Main Results:
- The patient presented with cyanosis, hypoxia, and unmeasurable blood pressure post-butylscopolamine administration.
- Biochemical markers of anaphylaxis (histamine, tryptase) were significantly elevated.
- Immunological tests confirmed butylscopolamine as the sole trigger for the anaphylactic reaction.
Conclusions:
- Butylscopolamine can precipitate severe anaphylactic events.
- Accurate identification of butylscopolamine as the allergen is crucial for preventing recurrent anaphylaxis.
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