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Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Satellite Stem Cells and Muscular Dystrophy01:21

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Desmosomes01:05

Desmosomes

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Related Experiment Video

Updated: Dec 24, 2025

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

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Anti-MDA5-associated dermatomyositis.

Rajiv Gupta1, Sunil Kumar1, Peter Gow1

  • 1Department of Rheumatology, Middlemore Hospital, Auckland, New Zealand.

Internal Medicine Journal
|April 10, 2020
PubMed
Summary
This summary is machine-generated.

Anti-MDA5-associated dermatomyositis is a rare autoimmune condition often leading to severe lung disease. Despite aggressive treatment, outcomes remain poor, highlighting the need for better therapeutic strategies.

Keywords:
MDA5-associated interstitial lung diseaseanti-MDA5-associated dermatomyositiscyclosporineinflammatory myopathyintravenous immunoglobulins

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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Area of Science:

  • Rheumatology
  • Pulmonology
  • Dermatology

Background:

  • Anti-melanoma differentiation-associated gene 5 (MDA5)-associated dermatomyositis (DM) is a rare autoimmune condition.
  • It is frequently amyopathic and linked to interstitial lung disease (ILD) with a poor prognosis.

Purpose of the Study:

  • To report two cases of anti-MDA5-associated DM with rapidly progressive ILD (RP-ILD).
  • To discuss treatment challenges and outcomes in these severe cases.

Main Methods:

  • Case report of two patients diagnosed with anti-MDA5-associated DM and RP-ILD.
  • Review of treatment strategies, including 'aggressive triple therapy', and patient outcomes.

Main Results:

  • One patient experienced a fatal outcome despite intensive treatment for RP-ILD.
  • The other patient's outcome is discussed in the context of treatment resistance.

Conclusions:

  • Anti-MDA5-associated DM with RP-ILD presents a significant therapeutic challenge.
  • Current treatment regimens may be insufficient for managing this severe presentation.