Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris

Area of Science:

• Cardiology
• Nephrology
• Public Health

Background:

• Coronary artery disease (CAD) is a leading cause of mortality worldwide.
• Renal dysfunction is an emerging risk factor for cardiovascular diseases.
• The association between mild renal dysfunction (MRD) and CAD in younger adults (<60 years) requires further investigation.

Purpose of the Study:

• To investigate the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD).
• To assess the association in individuals under 60 years of age with stable angina pectoris.

Main Methods:

• Retrospective study including 634 individuals with stable angina pectoris and eGFR ≥60 ml/min/1.73 m².
• Participants were divided into two groups: 317 with CAD (vessel stenosis ≥50%) and 317 with normal coronary angiography.
• Mild renal dysfunction (MRD) was defined based on estimated glomerular filtration rate (eGFR).

Main Results:

• Patients with CAD had a significantly lower mean eGFR (95.3 ± 23.7 ml/min/1.73 m²) compared to controls (109.7 ± 22.3 ml/min/1.73 m²; p=0.002).
• The prevalence of MRD was higher in the CAD group (43.2%) than in the control group (16.4%; p<0.001).
• Multivariate analysis identified lower eGFR as an independent risk factor for CAD in this population.

Conclusions:

• Mild renal dysfunction is associated with an increased risk of coronary artery disease in individuals under 60 years of age.
• Lower eGFR is an independent predictor of CAD in younger adults with stable angina.
• These findings highlight the importance of renal function assessment in cardiovascular risk stratification for younger patients.