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Updated: Dec 24, 2025

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
Published on: February 26, 2012
Comparing learning during the familiarization phase with a slanted mouse and a vertical mouse when performing a
Gaudez Clarisse1, François Cail1, Wild Pascal2
1Working Life Department, French Research and Safety Institute (INRS), France.
Abstract:
Purpose. Vertical and slanted mouse models have been developed to reduce forearm pronation. Discomfort, performance and stresses have been analyzed with these mice in previous studies but not learning during the familiarization phase. Methods. Eighteen females performed repeated pointing-clicking tasks with a standard mouse used as a reference followed by a slanted mouse and a vertical mouse in a randomized order. The duration of each task was measured. For each participant-mouse combination, changes in duration upon repeating the task were analyzed using a statistical model including a log-linear slope followed by a plateau. We consider that when the plateau is reached, the participant is familiar with the task. Results. For both the slanted mouse and the vertical mouse, the plateau is reached after about 30 repetitions of the task. The duration of the plateau was similar for these two mouse models. For the vertical mouse only, the slope increased significantly when used second versus when used first. Conclusion. Learning speed appeared slower with the vertical mouse than with the slanted mouse. In light of these findings and those of previous studies, decision-makers and employees should consider the slanted mouse rather than the vertical mouse.

