Circular dichroism of mitomycin-DNA complexes. Evidence for a conformational change in DNA

Reductive activation of mitomycin A by thiols.

Organic letters·2001

Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.

Biochemistry·2001

Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential.

Journal of medicinal chemistry·2001

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.

Biochemical pharmacology·2001

Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.

Chemical research in toxicology·2000

Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity.

Bioorganic & medicinal chemistry·2000

Spontaneous Refolding of Escherichia coli Methionine Adenosyltransferase (MetK) Is Extremely Slow, Indicative of Chaperone Dependence.

Biochemistry·2026

Mena EVH1 Interacts with PTP1B Via a Distributed Interface Without Regulating Enzymatic Activity.

Biochemistry·2026

Development of a FRET-Based Assay for Human Neutral Sphingomyelinase 2.

Biochemistry·2026

Suppression of Thermal Protein Aggregation by Acetylation of Lysine Side Chains.

Biochemistry·2026

A Pair of FAD-Dependent Carbohydrate Oxidases from the Corn Smut Pathogen Ustilago maydis Oxidize Chitosan Oligomers.

Biochemistry·2026

Energetic Determinants of Expanded PAM Recognition in Engineered FnCas9.

Biochemistry·2026

Ambient Laser Desorption Low-Pressure Dopant-Assisted Photoionization Mass Spectrometry for Detection of Nicotine and Caffeine in Single Human Hair.

Analytical chemistry·2026

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3-Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia.

Phytotherapy research : PTR·2026

MMP2 sheds Glypican-4 to suppress Slit3-Robo4 signaling and angiogenesis.

Proteoglycan research·2026

Related Experiment Videos

Circular dichroism of mitomycin-DNA complexes. Evidence for a conformational change in DNA

Related Concept Videos

Reductive activation of mitomycin A by thiols.

Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.

Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential.

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.

Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.

Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity.

Spontaneous Refolding of Escherichia coli Methionine Adenosyltransferase (MetK) Is Extremely Slow, Indicative of Chaperone Dependence.

Mena EVH1 Interacts with PTP1B Via a Distributed Interface Without Regulating Enzymatic Activity.

Development of a FRET-Based Assay for Human Neutral Sphingomyelinase 2.

Suppression of Thermal Protein Aggregation by Acetylation of Lysine Side Chains.

A Pair of FAD-Dependent Carbohydrate Oxidases from the Corn Smut Pathogen Ustilago maydis Oxidize Chitosan Oligomers.

Energetic Determinants of Expanded PAM Recognition in Engineered FnCas9.

Ambient Laser Desorption Low-Pressure Dopant-Assisted Photoionization Mass Spectrometry for Detection of Nicotine and Caffeine in Single Human Hair.

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3-Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia.

MMP2 sheds Glypican-4 to suppress Slit3-Robo4 signaling and angiogenesis.

A Narrative Review of the Multi-Target Mechanisms of Glabridin in Skin Lightening.

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Circular dichroism of mitomycin-DNA complexes. Evidence for a conformational change in DNA

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