Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

138
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
138
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

669
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
669
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

143
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
143
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.5K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.5K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.4K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.4K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

3.4K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remodeling-Mediated Changes in Left Ventricular Mechanics Under Settings of Chronic Pressure Overload and Exercise.

Journal of biomechanical engineering·2026
Same author

Vision-language framework for multi-sequence brain magnetic resonance imaging.

medRxiv : the preprint server for health sciences·2026
Same author

Domain-adapted language model using reinforcement learning for various dementias.

medRxiv : the preprint server for health sciences·2026
Same author

Predicting cognitive impairment using novel functional features of spatial proximity and circularity in the digital clock drawing test.

medRxiv : the preprint server for health sciences·2026
Same author

Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Intravascular Ultrasound is More Accurate Than Angiography in Arteriovenous Vascular Access Lesions.

Kidney360·2026

Related Experiment Video

Updated: Dec 24, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.2K

Surface Modification Using Ultraviolet-Ozone Treatment Enhances Acute Drug Transfer in Drug-Coated Balloon Therapy.

Dara Azar, Jared T Lott, Ehsan Jabbarzadeh

  • 1Hariri Institute for Computing and Computational Science and Engineering, Boston University, Boston, Massachusetts 02215, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 10, 2020
PubMed
Summary

Improving drug-coated balloons (DCB) involves enhancing drug delivery to the arterial wall. Ultraviolet-ozone plasma treatment boosts balloon hydrophilicity, improving paclitaxel transfer for better revascularization strategies.

More Related Videos

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

685
Functionalization and Dispersion of Carbon Nanomaterials Using an Environmentally Friendly Ultrasonicated Ozonolysis Process
08:33

Functionalization and Dispersion of Carbon Nanomaterials Using an Environmentally Friendly Ultrasonicated Ozonolysis Process

Published on: May 30, 2017

10.5K

Related Experiment Videos

Last Updated: Dec 24, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

4.2K
Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting
08:53

Artificial Lung Device Priming for In Situ Fiber Bundle Surface Grafting

Published on: March 28, 2025

685
Functionalization and Dispersion of Carbon Nanomaterials Using an Environmentally Friendly Ultrasonicated Ozonolysis Process
08:33

Functionalization and Dispersion of Carbon Nanomaterials Using an Environmentally Friendly Ultrasonicated Ozonolysis Process

Published on: May 30, 2017

10.5K

Area of Science:

  • Biomaterials Engineering
  • Vascular Biology
  • Drug Delivery Systems

Background:

  • Drug-coated balloons (DCB) are used for arterial revascularization.
  • Concerns exist regarding paclitaxel-eluting DCB safety and drug delivery efficiency.
  • Current DCB designs have limitations in drug transfer and retention.

Purpose of the Study:

  • To develop a strategy for enhanced acute drug transfer from DCBs to the arterial wall.
  • To investigate the use of ultraviolet-ozone (UVO) plasma treatment for balloon surface modification.
  • To evaluate the impact of coating microstructure on drug transfer efficiency.

Main Methods:

  • Nylon-12 balloon material was treated with UVO plasma to increase hydrophilicity.
  • A urea-paclitaxel coating was applied to the modified balloons.
  • Assays were conducted to characterize balloon surface changes, coating microstructure, stability, and acute drug transfer.

Main Results:

  • UVO treatment successfully increased the hydrophilicity of the Nylon-12 balloon surface.
  • The urea-paclitaxel coating exhibited favorable adhesive interactions with the arterial wall.
  • Coating microstructure was identified as a critical factor influencing drug transfer efficiency.

Conclusions:

  • UVO-based surface modification is a promising strategy for improving DCB design.
  • Enhanced drug transfer efficiency can be achieved through optimized coating microstructure.
  • This approach holds potential for safer and more effective DCB-based revascularization therapies.