Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiac Action Potential01:30

Cardiac Action Potential

5.2K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
5.2K
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

16.4K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
16.4K
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

3.8K
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
3.8K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

8.5K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
8.5K
Development of the Heart01:27

Development of the Heart

1.8K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Subtype Identification and Prognostic Prediction of Pancreatic Cancer Based on m6A/m5C/m1A-Related Genes.

Journal of cellular and molecular medicine·2026
Same author

SORBS2 regulates diastolic function through cytoskeletal networks and calcium handling.

Communications biology·2026
Same author

Deep learning based individualized cross-platform molecular subtype classification of B-lineage acute lymphoblastic leukemia.

NPJ precision oncology·2026
Same author

Synergistic engineering of intralayer conjugation and interlayer stacking within pyrene-based covalent organic frameworks for efficient hydrogen peroxide production and amidation oxidation.

Journal of colloid and interface science·2026
Same author

SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure.

Circulation·2026
Same author

CRISPR/Cas9 mediated knockout of MeSSI enhances resistant starch content without compromising yield in cassava.

Carbohydrate polymers·2026
Same journal

Mitochondrial STING Governs Glycolytic Reprogramming in Diabetic Cardiomyopathy.

Circulation research·2026
Same journal

Hypoxia-Induced Epas1-Myl9/12 Axis Shapes the Pathology of Pulmonary Hypertension.

Circulation research·2026
Same journal

Proteogenomics of Hypertrophic Cardiomyopathy Reveals Subtype-Specific Therapy.

Circulation research·2026
Same journal

Impaired Endothelial Cell Cholesterol Metabolism Promotes Vascular Inflammation in Sleep Apnea.

Circulation research·2026
Same journal

Engineered Heart Tissues Facilitate Noncoding Variant Studies in Cardiomyopathy.

Circulation research·2026
Same journal

NUAK1 Inhibition Alleviates Ischemia-Reperfusion Injury via SYNE1-YAP1.

Circulation research·2026
See all related articles

Related Experiment Video

Updated: Dec 24, 2025

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
10:56

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

21.8K

Cardiomyocyte Maturation: New Phase in Development.

Yuxuan Guo1, William T Pu2

  • 1From the Department of Cardiology, Boston Children's Hospital, MA (Y.G., W.T.P.).

Circulation Research
|April 10, 2020
PubMed
Summary
This summary is machine-generated.

Cardiomyocyte maturation is crucial for heart function, involving specialized cellular changes from fetal to adult states. Understanding these processes aids in developing better stem cell therapies and treating heart disease.

Keywords:
heart diseasemammalspluripotent stem cellregenerationstem cell

More Related Videos

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

2.3K
Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes
09:41

Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes

Published on: February 24, 2017

9.0K

Related Experiment Videos

Last Updated: Dec 24, 2025

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
10:56

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

21.8K
High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
14:03

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers

Published on: March 24, 2023

2.3K
Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes
09:41

Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes

Published on: February 24, 2017

9.0K

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Cellular Specialization

Background:

  • Heart maturation is the final stage of cardiac development, essential for lifelong pumping efficiency.
  • Cardiomyocyte maturation involves significant structural, gene expression, metabolic, and functional changes.
  • Recent interest stems from maturation defects in stem cell-derived cardiomyocytes, impacts on regeneration, and links to cardiac disease.

Purpose of the Study:

  • To review the key features of ventricular cardiomyocyte maturation.
  • To summarize the regulatory mechanisms governing cardiomyocyte maturation.
  • To highlight the implications for stem cell therapies and heart disease.

Main Methods:

  • Literature review of cardiomyocyte maturation.
  • Analysis of structural, molecular, and functional changes.
  • Synthesis of regulatory pathways.

Main Results:

  • Identified major hallmarks of ventricular cardiomyocyte maturation.
  • Summarized key regulatory mechanisms coordinating these cellular events.
  • Discussed the relevance of maturation defects and research advancements.

Conclusions:

  • Understanding cardiomyocyte maturation is vital for improving stem cell-derived cardiomyocytes.
  • Advances in research platforms promise deeper insights into cardiac development.
  • This knowledge can lead to novel therapeutic strategies for heart disease.