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PrEP for HIV Prevention: Evidence, Global Scale-up, and Emerging Options
1University of Washington, Seattle, WA, USA.
Cell Host & Microbe
|April 10, 2020
Summary
Antiretroviral pre-exposure prophylaxis (PrEP) is a safe and effective HIV prevention method. New formulations aim to improve access and increase coverage for greater public health impact.
Area of Science:
- Infectious Diseases
- Public Health
- Pharmacology
Background:
- Oral emtricitabine-tenofovir disoproxil fumarate demonstrated efficacy and safety for HIV prevention.
- Regulatory approval and global guidance have expanded access to pre-exposure prophylaxis (PrEP).
- Demonstration projects show high uptake and population-level HIV reductions.
Purpose of the Study:
- To highlight the need for simplified delivery of PrEP.
- To address barriers to PrEP access and persistence.
- To introduce next-generation PrEP formulations for increased user choice and coverage.
Main Methods:
- Review of pivotal studies on oral emtricitabine-tenofovir disoproxil fumarate.
- Analysis of regulatory approvals and global normative guidance.
- Evaluation of data from PrEP demonstration projects.
Main Results:
- PrEP using oral emtricitabine-tenofovir disoproxil fumarate is proven efficacious and safe.
- Widespread regulatory approval and implementation in numerous countries.
- Successful demonstration projects with high uptake and significant HIV reduction.
Conclusions:
- Simplifying PrEP delivery and reducing access barriers are crucial.
- Next-generation PrEP formulations under development offer potential for increased choice and impact.
- Expanding PrEP coverage is key to further reducing the HIV epidemic.
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