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Related Experiment Video

Updated: Jun 5, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
09:27

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues

Published on: February 17, 2017

Trehalase deficiency in Greenland.

E Gudmand-Høyer1, H J Fenger, H Skovbjerg

  • 1Medical-Gastroenterological Dept. F, Gentofte Hospital, University of Copenhagen, Denmark.

Scandinavian Journal of Gastroenterology
|September 1, 1988
PubMed
Summary

At least 8% of adult Greenlanders have trehalase deficiency, a condition found not to impact nutrition. This study investigated its prevalence and implications in the Greenlandic population.

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Area of Science:

  • Gastroenterology
  • Human Genetics
  • Nutritional Science

Background:

  • Trehalase is an enzyme crucial for digesting trehalose, a disaccharide found in fungi and insects.
  • The prevalence and clinical significance of trehalase deficiency in various populations remain incompletely understood.

Purpose of the Study:

  • To determine the incidence of trehalase deficiency in adult Greenlanders.
  • To assess the clinical and nutritional implications of trehalase deficiency in this population.

Main Methods:

  • Analysis of small-intestinal surgical biopsy specimens from 97 adult Greenlanders.
  • Performance of trehalose tolerance tests in individuals with low trehalase activity.

Main Results:

  • An incidence of at least 8% for trehalase deficiency was observed in the studied Greenlandic population.
  • Trehalose tolerance tests in deficient individuals showed no significant increase in blood glucose levels.
  • Co-occurrence of lactase deficiency was noted in three trehalase-deficient patients.

Conclusions:

  • Trehalase deficiency is relatively common in adult Greenlanders.
  • The condition does not appear to have significant nutritional implications.
  • Further research may explore the genetic basis and potential co-morbidities like lactase deficiency.