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Published on: September 13, 2016
Effect of internal limiting membrane peeling on normal retinal function evaluated by microperimetry-3.
Yue Qi1, Zengyi Wang1, Shi-Ming Li1
1Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaomminxiang Street, Dongcheng District, Beijing, 100730, China.
Internal limiting membrane (ILM) peeling during macular hole surgery improves retinal sensitivity without compromising function in the surrounding retina. This procedure demonstrates short-term safety and efficacy for retinal function assessment.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Visual Function Assessment
Background:
- Macular holes (MH) are a common cause of vision loss.
- Internal limiting membrane (ILM) peeling is a surgical technique used in MH repair.
- The effect of ILM peeling on surrounding retinal function requires evaluation.
Purpose of the Study:
- To assess the functional impact of ILM peeling on the retina surrounding macular holes.
- To evaluate changes in retinal sensitivity using microperimetry-3 (MP-3) post-surgery.
Main Methods:
- Prospective cohort study of 44 patients undergoing vitrectomy with ILM peeling for MH.
- Pre- and post-operative assessments included color fundus photography, OCT, and MP-3.
- MP-3 used a 45-spot pattern in the central 8° visual field, focusing on the perimacular area.
Main Results:
- Anatomical success was achieved in all eyes at 4 months.
- Best corrected visual acuity (BCVA) significantly improved post-operatively.
- Mean retinal sensitivity (MRS) in the surrounding retina significantly increased at 1 and 4 months (P<0.01).
- Younger patients showed greater MRS improvement.
- Increased MRS was more pronounced in the inferior and nasal retina.
Conclusions:
- ILM peeling in the normal retina does not impair short-term retinal function.
- The procedure is associated with improved retinal sensitivity in the perimacular area.
- Further research may explore long-term functional outcomes and regional differences.
