Learning from clinical trials of neoadjuvant checkpoint blockade

Judith M Versluis1,2, Georgina V Long3,4, Christian U Blank5,6

  • 1Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Nature Medicine
|April 11, 2020
PubMed

Insights

Neoadjuvant checkpoint inhibition before surgery shows promise for melanoma and other cancers, with high response rates correlating to survival. This approach enables reverse translation to refine future cancer therapies.

Area of Science:

  • Oncology
  • Immunotherapy
  • Translational Research

Background:

  • Neoadjuvant checkpoint inhibition is an emerging strategy for managing resectable melanoma and other solid tumors.
  • This pre-surgical therapy demonstrates high pathologic response rates, which are linked to improved survival outcomes.

Purpose of the Study:

  • To discuss the rationale behind neoadjuvant immunotherapy using preclinical and translational data.
  • To summarize recent clinical trial results and ongoing research in this field.
  • To explore future directions for enhancing reverse translation to optimize patient outcomes.

Main Methods:

  • Review of preclinical studies and human translational data.
  • Analysis of results from recent clinical trials.
  • Discussion of ongoing research and future strategies.

Main Results:

  • Neoadjuvant immunotherapy exhibits a high pathologic response rate in clinical trials.
  • Pathologic response is a significant correlate of patient survival outcomes.
  • Biopsies obtained routinely facilitate understanding of therapy response and reverse translation.

Conclusions:

  • Neoadjuvant immunotherapy is a promising strategy for resectable solid tumors, particularly melanoma.
  • Reverse translation of clinical data is crucial for refining and personalizing future treatment strategies.
  • Further research is needed to optimize neoadjuvant immunotherapy and its translational applications.

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