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Updated: Dec 24, 2025

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Frail Older Individuals Maintaining a Steady Standing Position: Associations Between Sway Measurements with Frailty
Samuel Schülein1, Cornel Christian Sieber2,3, Karl-Günter Gaßmann1,2
1Geriatrics Centre Erlangen, Malteser Waldkrankenhaus St. Marien, Erlangen, Germany.
Objective:
An analysis of the relationships between static equilibrium parameters and frailty status and/or severity across four different frailty measures.
Design:
Cross-sectional analysis.
Setting:
Geriatric wards of a general hospital.
Participants:
One hundred twenty-three geriatric inpatients comprising 70 women (56.5%) and 53 men (42.7%) with an age range of 68-95 years.
Methods:
The variation in the center of pressure (CoP), ie, the length of sway, the area of sway, and the mean speed, was assessed for different positions/tasks: 1) wide standing with eyes open (WSEO); 2) wide standing with eyes closed (WSEC); 3) narrow standing with eyes open (NSEO) and 4) narrow standing with eyes closed (NSEC), using a force plate. Frailty status and/or frailty severity were evaluated using the frailty phenotype (FP), the clinical frailty scale (CFS), the 14-item frailty index based on a comprehensive geriatric assessment (FI-CGA), and a 47-item frailty index (FI).
Results:
WSEO length of sway (FP, CFS, FI-CGA, FI), WSEO area of sway (FP, CFS, FI-CGA, FI), and WSEO mean speed (FP, CFS, FI-CGA, FI), WSEC length of sway (FP, FI-CGA, FI), WSEC area of sway (FP, FI-CGA, FI) and WSEC mean speed (FI-CGA, FI), NSEO length of sway (FP, FI-CGA, FI), NSEO area of sway (FP, CFS, FI-CGA, FI), and NSEO mean speed (FP, CFS, FI-CGA, FI), NSEC length of sway (FI-CGA, FI), NSEC area of sway (FI-CGA, FI) and NSEC mean speed (FI-CGA, FI) were associated with the frailty status and/or severity across the four different frailty instruments (all p < 0.05, respectively).
Conclusion:
Greater fluctuations in CoP with increasing frailty status and/or severity were a uniform finding across various major frailty instruments.
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