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[Retinal detachment after intravitreal ocriplasmin injection].

Michael Müller1, Frank Koch1, Pankaj Singh1

  • 1Klinik für Augenheilkunde, Universitätsklinikum Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|April 11, 2020
PubMed
Summary

Intravitreal injection of Ocriplasmin for vitreomacular traction caused severe retinal detachment. This case highlights a rare but serious complication requiring further investigation and preoperative discussion.

Keywords:
IVIJetreaVitrectomyVitreomacular traction (VMT)Vitreous body detachment

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Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Pharmacology

Background:

  • Vitreomacular traction (VMT) and macular holes can impair visual acuity.
  • Intravitreal injections (IVI) are a common treatment for various retinal conditions.
  • Ocriplasmin is an enzyme used to facilitate posterior vitreous detachment.

Purpose of the Study:

  • To report a case of severe retinal detachment following Ocriplasmin IVI.
  • To highlight a potential, excessive reaction to Ocriplasmin.
  • To emphasize the importance of informed consent regarding IVI risks.

Main Methods:

  • A single patient case study.
  • Administration of Ocriplasmin via intravitreal injection.
  • Observation of post-injection complications.

Main Results:

  • The patient developed retinal detachment days after Ocriplasmin IVI.
  • An excessive reaction in the vitreous body caused severe retinal traction.
  • This led to posterior vitreous detachment, retinal holes, and complete retinal detachment.

Conclusions:

  • Ocriplasmin IVI can lead to severe retinal detachment due to excessive vitreous reaction.
  • This complication, though rare, necessitates thorough preoperative patient counseling.
  • Further research is needed to understand the mechanism of this excessive reaction.