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COVID-19 in the heart and the lungs: could we "Notch" the inflammatory storm?

Paola Rizzo1,2, Francesco Vieceli Dalla Sega3, Francesca Fortini3

  • 1Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. rzzpla@unife.it.

Basic Research in Cardiology
|April 11, 2020
PubMed

Insights

This study explores targeting Notch signaling to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mitigate COVID-19-related heart and lung complications. Modulating this pathway may offer a novel therapeutic strategy for viral infections and associated cardiovascular disease.

Area of Science:

  • Cardiovascular Biology
  • Virology
  • Molecular Signaling

Background:

  • Coronavirus disease (COVID-19), caused by SARS-CoV-2, has led to a global health crisis.
  • Cardiac complications like myocarditis and heart failure are observed in COVID-19 patients, indicating a link between SARS-CoV-2 infection and cardiovascular disease.
  • Notch signaling is crucial for cardiovascular function and plays a role in viral infection pathways.

Discussion:

  • This report investigates the potential of targeting Notch signaling as a therapeutic strategy against SARS-CoV-2.
  • Interfering with Notch signaling could prevent viral entry or replication.
  • Modulating Notch signaling may also address COVID-19-associated cardiac and pulmonary pathologies.

Key Insights:

  • A potential therapeutic target for COVID-19 and its cardiac sequelae is identified.
  • The role of Notch signaling in both cardiovascular health and viral pathogenesis is highlighted.
  • This research opens avenues for novel treatment strategies.

Outlook:

  • Further research is needed to validate Notch signaling as a therapeutic target for COVID-19.
  • Preclinical and clinical studies are required to assess the safety and efficacy of Notch pathway modulators.
  • This approach could lead to new treatments for viral myocarditis and other cardiovascular complications.

Keywords:
ADAM17Angiotensin-converting enzyme 2COVID-19Cardiovascular diseaseCoronavirus diseaseFurinNotch

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