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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
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Altered Proteostasis in Neurodegenerative Tauopathies
Katerina Papanikolopoulou1, Efthimios M C Skoulakis2
1Institute for Fundamental Biomedical Research, Biomedical Sciences Research Centre "Alexander Fleming", Vari, Greece.
Advances in Experimental Medicine and Biology
|April 11, 2020
Summary
Tauopathies involve abnormal Tau protein accumulation, forming aggregates like neurofibrillary tangles. This study explores how proteostasis mechanisms fail, offering insights into biomarkers and therapeutic targets for these neurodegenerative diseases.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- Tauopathies are neurodegenerative diseases characterized by abnormal Tau protein.
- Hyperphosphorylated Tau aggregates into structures like neurofibrillary tangles.
- The failure of proteostasis mechanisms in Tau accumulation remains unclear.
Purpose of the Study:
- To investigate the role of proteostasis systems in Tauopathy.
- To understand how Tau proteins elude cellular surveillance.
- To identify potential diagnostic biomarkers and therapeutic targets.
Main Methods:
- Review of Ubiquitin-Proteasome system, autophagy, and ER-Unfolded Protein Response in Tauopathy models and patients.
- Analysis of interactions between Tau and proteostasis components.
- Examination of pathological Tau's effects on cellular systems.
Main Results:
- Proteostasis systems show interactions with Tau in models and patients.
- Pathological Tau impacts these systems, leading to aggregation.
- These interactions suggest mechanisms of Tau accumulation.
Conclusions:
- Dysfunctional proteostasis contributes to Tau aggregation and neurodegeneration.
- Interactions between Tau and proteostasis pathways offer potential biomarkers.
- Targeting these interactions may provide therapeutic strategies for Tauopathies.
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