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Updated: Dec 24, 2025
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
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Thyroid cancer histological subtypes based on tumor size: National perspective
Zaid Al-Qurayshi1, Megan J Foggia1, Nitin Pagedar1
1Department of Otolaryngology-Head & Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Head & Neck
|April 11, 2020
Summary
Thyroid cancer management varies by tumor size. Larger tumors (>4 cm) include more aggressive subtypes, while smaller tumors (≤4 cm) may face increased staged thyroidectomy risk, especially in low-volume hospitals.
Area of Science:
- Endocrinology
- Surgical Oncology
- Cancer Research
Background:
- Thyroid tumor size is a critical prognostic indicator in thyroid cancer.
- Understanding histological subtypes and management strategies based on tumor size is essential.
Purpose of the Study:
- To analyze histological subtypes of thyroid cancer.
- To compare the management of thyroid cancer based on tumor size (≤4 cm vs >4 cm).
Main Methods:
- Retrospective cohort study.
- Utilized the National Cancer Database (2004-2014).
- Included 152,387 patients.
Main Results:
- 8.9% of patients had tumors >4 cm.
- Papillary thyroid carcinoma was the most common subtype (>4 cm).
- High-volume hospitals were less likely to perform two-stage thyroidectomy, especially for smaller tumors; low-volume hospitals had higher staged thyroidectomy rates for medullary thyroid carcinoma (MTC) ≤4 cm.
Conclusions:
- The study highlights the prevalence of thyroid cancer subtypes.
- A conservative approach to differentiated thyroid carcinoma may increase the risk of staged thyroidectomy.
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