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Updated: Aug 15, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
Plasma fibrinolytic activity in sickle cell disease
1Department of Haematology, College of Medical Sciences, University of Benin, Bendel State, Nigeria.
Abstract:
Changes in plasma fibrinolytic activity, as measured by euglobulin lysis time (ELT) and serum fibrinogen degradation products (FDP) were investigated in 70 Nigerians with homozygous (HbSS) sickle cell disease (SCD), (50 in stable state and 20 in crisis state) and 75 age-matched non-sicklers. All had normal hemoglobin genotype (HbAA). The levels of ELT and FDP were significantly higher in sicklers in steady state than non-sicklers, but significantly lowered in sicklers in crisis than both non-sicklers and sicklers in stable state. Disturbances of fibrinolytic mechanism in both steady and crisis state might have a relationship to the clinical state of the individual patient.
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