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Self-assembled multifunctional core-shell highly porous metal-organic framework nanoparticles.

Jingwen Qiu1, Xue Li1, Karine Steenkeste1

  • 1Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, 91405 Orsay, France.

International Journal of Pharmaceutics
|April 11, 2020
PubMed
Summary

Novel biodegradable cyclodextrin (CD) shells were developed for porous nanoscale metal-organic frameworks (nanoMOFs). These core-shell nanoMOFs show enhanced stability and drug loading, improving nanomedicine applications.

Keywords:
DoxorubicinMetal organic frameworksSelf assembleSurface modificationγ-cyclodextrin-citrate oligomers

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Area of Science:

  • Nanomedicine
  • Materials Science
  • Drug Delivery

Background:

  • Core-shell nanoparticles (NPs) offer unique properties by combining different materials.
  • Porous nanoscale metal-organic frameworks (nanoMOFs) can carry high drug payloads but require functional coatings for stability and controlled release.

Purpose of the Study:

  • To design and synthesize a novel biodegradable cyclodextrin (CD)-based shell for porous nanoMOFs.
  • To enhance the stability, drug loading capacity, and in vivo characteristics of nanoMOFs.

Main Methods:

  • Synthesis of water-soluble γ-cyclodextrin (γ-CD)-citrate oligomers using citric acid as a crosslinker.
  • Anchoring of γ-CD-citrate oligomers, with or without fluorophore grafting, onto porous nanoMOFs.
  • Characterization of the resulting core-shell nanocomposites, including coating efficiency, stability, and drug loading capacity.
  • Utilizing fluorescence-lifetime microscopy to investigate the coating mechanism.

Main Results:

  • High yields (up to 86%) and significant amounts (53 ± 8 wt%) of γ-CD-citrate oligomers were achieved on nanoMOFs.
  • The synthesized core-shell nanocomposites demonstrated improved stability compared to naked nanoMOFs and prevented aggregation of doxorubicin (DOX)-loaded nanoMOFs.
  • Doxorubicin (DOX) loading reached 65 ± 8 wt% after coating and incubation.
  • Fluorophore conjugation allowed visualization of the coating mechanism via fluorescence-lifetime microscopy.

Conclusions:

  • Biodegradable cyclodextrin-based oligomeric shells effectively functionalize porous nanoMOFs.
  • These core-shell nanoMOFs exhibit enhanced colloidal stability and high drug loading capacity, making them promising for nanomedicine.
  • The developed coating strategy offers a versatile platform for creating functionalized nanoMOFs for drug delivery applications.