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A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
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A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

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Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes

Eric Owusu Obeng1, Isabella Rusciano1, Maria Vittoria Marvi1

  • 1Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.

International Journal of Molecular Sciences
|April 12, 2020
PubMed

Insights

Phosphoinositide-specific phospholipase C (PLC) enzymes are crucial in cancer, regulating cell survival and proliferation. This review details PLC involvement in various cancer types, focusing on PLCβ, PLCγ, PLCδ, and PLCε isoforms.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Phosphoinositides (PI) are minor cell components but critical in cancer progression.
  • Specific PIs like PtdIns(3,4,5)P3 and PtdIns(4,5)P2 regulate key cancer cell behaviors.
  • Phosphoinositide-specific phospholipase C (PLC) enzymes hydrolyze PtdIns(4,5)P2, generating second messengers.

Purpose of the Study:

  • To review the current understanding of phosphoinositide-specific phospholipase C (PLC) involvement in cancer.
  • To highlight the roles of PLCβ, PLCγ, PLCδ, and PLCε isoforms in oncogenesis.

Main Methods:

  • Literature review of studies on PLC isoforms and their functions in cancer.
  • Analysis of evidence linking PLC activity to cancer cell survival, proliferation, invasion, and growth.

Main Results:

  • Diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (InsP3) produced by PLC regulate Protein Kinase C (PKC) and calcium release.
  • These signaling events are implicated in numerous biological processes vital to cancer.
  • Specific PLC isoforms (PLCβ, PLCγ, PLCδ, PLCε) show significant involvement across various cancer types.

Conclusions:

  • Phosphoinositide-specific phospholipase C enzymes play multifaceted roles in cancer development and progression.
  • Further research is needed to fully elucidate the regulatory mechanisms of PLCs in oncogenic processes.
Keywords:
cancerphosphatidylinositolphosphoinositidesphospholipase C

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